1.
Pediatr Dermatol
; 41(1): 108-111, 2024.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37571864
RESUMO
Port wine birthmarks (PWB) are capillary vascular malformations within the papillary and reticular dermis, most commonly occurring on the head and neck and may darken and thicken with age. Pulsed dye laser (PDL) is the gold standard of treatment for PWB as it selectively targets involved vessels. Sirolimus is a macrolide antibiotic that selectively inhibits mammalian target of rapamycin, thereby suppressing the angiogenesis pathways that can be activated by PDL. Sirolimus and PDL may be used together to treat PWB. We present a case series describing three cases of delayed ulceration and systemic sirolimus absorption following combination therapy, highlighting a potential complication and patient safety concern.
Assuntos
Capilares/anormalidades , Terapia a Laser , Lasers de Corante , Mancha Vinho do Porto , Malformações Vasculares , Humanos , Sirolimo/efeitos adversos , Lasers de Corante/efeitos adversos , Imunossupressores , Mancha Vinho do Porto/cirurgia , Administração Tópica , Resultado do Tratamento
2.
J Am Acad Dermatol
; 88(2): 513-514, 2023 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35318106
3.
Cutis
; 110(2): E42-E44, 2022 08.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36219646